Unlike conventional batch synthesis, flow synthesis enables safe and speedy material production using very compact equipment, which fits chemical manufacturing in line with the SDGs.
Recent References:
- Flow Chemistry Concept: CSIRO, Merbourne, https://www.youtube.com/watch?v=D-VJy4d7tUY
- Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products, Org. Process Res. Dev. 2016, 20, 2-25
- A Perspective on Continuous Flow Chemistry in the Pharmaceutical Industry, Org. Process Res. Dev. 2020, 24, 10, 1802–1813
- Improved efficiency of photo-induced synthetic reactions enabled by advanced photo flow technologies, Photochem. Photobiol. Sci. 2022, 21 , 761-775.
- Continuous flow technology-a tool for safer oxidation chemistry, React. Chem. Eng., 2022, 7, 490-550.
- Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients, React. Chem. Eng., 2022,7, 214-244
- Application of reactor engineering concepts in continuous flow chemistry: a review, React. Chem. Eng., 2021,6, 1295-1326
Why Flow?What flow synthesis can do
Innovations
Photolflow reaction technology
- C-H functionalization reaction
- Halogenation reaction
- Photoredox catalyzed reaction
Thermally controlled flow reaction technology
- Heat-added reaction
- Heat-removed reaction
- Cycloaddition reaction
- Radical reaction
Immobilized catalyst for flow reaction technology
- Esterification reaction
- Hydrogenation reaction
- C-C bond forming reaction
Flow polymerization technology
- Living radical polymerization
- Living anionic polymerization
Gas-liquid two-phase flow reaction technology
- Carbonylation reaction
- Oxygen oxidation reaction
- Chlorination reaction
Continuous flow reaction technology
- Droplet reaction
- Gravity separation method
- Automatic parallel synthesis method