Our products strongly support flow chemistry research in academia.
Continuous Flow Oxidation of Alcohols to Carboxylic Acids Using a Ternary Pd/C-Pt/C-Ru/C Catalyst and Molecular Oxygen. Application to the Synthesis of 2,5-Frandicarboxylic Acid
Mamoru Hyodo, Yusuke Takahashi, Yiyue Yao, Kinryo Cho, Takahide Fukuyama, Ilhyong Ryu
ChemistryEurope, 2025, e202500246
The Use of a Diagonal Photoflow System Combined with a High-Power UV LED in High-Speed C-H Bromination Reactions
Fukuyama, T.; Kasakado, T.; Takahashi, Y.; Takamura, K.; Ryu, I.
Asian J. Org. Chem. 2025, 17, e202500292.
Flow Deprotection of tert-Butyl Ester of Poly(n-Butyl Methacrylate-b-tert-Butyl Methacrylate) by Solid Catalysts Leading to Acidic Di-block Copolymers
R. Takabayashi, S. Feser, H. Yonehara, M. Hyodo, I. Ryu, T. Fukuyama
Polymer Journal, 2025, 57, 215-224.
Efficient Flow Synthesis of Glycidyl Ether Using BuSnCl3 as a Mild Lewis Acid
Kasakado, T.; Nakamura, M.; Nishizawa, A.; Hosomi, T.; Ryu, I.; Fukuyama, T.
Synthesis, 2024, 56, 3142-3146.
Photo Flow Protocol for Bromoallylation of Alkynes and Alkenes
Fukuyama, T.; Dakegata, A.; Ryu, I.
Arkivoc 2024, 2, 202312077.
Photocatalytic Oxidative Cleavage of Alkenes by Molecular Oxygen: Reaction Scope, Mechanistic Insights, and Flow Application
Shih, Y.-L.; Wu, Y.-K.; Hyodo, M.; Ryu, I.
J. Org. Chem. 2023, 88, 6548-6552.
Photocatalytic C(sp3)-H Thiolation by a Double SH2 Strategy Using Thiosulfonates
Taniguchi, N.; Hyodo, M.; Pan, L.-W.; Ryu, I.
Chem. Commun. 2023, 59, 14859-14862.
Accelerated Nitroxide-Mediated Polymerization of Styrene and Butyl Acrylate Initiated by BlocBuilder MA Using Flow Reactors
Takabayashi, R.; Feser, S.; Yonehara, H.; Ryu, I.; Fukuyama, T.
Polymer Chem. 2023, 14, 4515-4520.
Improved Efficiency of Photo-Induced Synthetic Reactions Enabled by Advanced Photo Flow Technologies
Fukuyama, T.; Kasakado, T.; Hyodo, M.; Ryu, I.
Photochem. Photobiol. Sci. 2022, 21, 761-775.
High-Speed C-H Chlorination of Ethylene Carbonate Using a New Photoflow Setup
Kasakado, T.; Fukuyama, T.; Nakagawa, T.; Taguchi, S.; Ryu, I.
Beilstein J. Org. Chem. 2022, 18, 152-158.
Using High-Power UV-LED to Accelerate a Decatungstate-Anion-Catalyzed Reaction: A Model Study for the Quick Oxidation of Benzyl Alcohol to Benzoic Acid Using Molecular Oxygen
Hyodo, M.; Iwano, H.; Kasakado. T.; Fukuyama, T.; Ryu, I.
Micromachines 2021, 12, 1307-1315.
Greener Synthesis of Pristane by Flow Dehydrative Hydrogenation of Allylic Alcohol Using a Packed-Bed Reactor Charged by Pd/C as a Single Catalyst
Kasakado,T.; Hirobe, Y.; Furuta, A.; Hyodo, M.; Fukuyama, T.; Ryu, I.
Molecules 2021, 26, 5845-5853.
Flow Friedel-Crafts Alkylation of 1-Adamantanol with Arenes Using HO-SAS as an Immobilized Acid Catalyst
Kasakado, T.; Hyodo, M.; Furuta, A.; Kamardine, A.; Ryu, I.; Fukuyama, T.
J. Chin. Chem. Soc. 2020, 67, 2253-2257.
Syntheses of Diarylethenes by Perylene-Catalyzed Photodesulfonylation from Ethenyl Sulfones
Watanabe, H.; Takemoto, M.; Adachi, K.; Okuda, Y.; Dakegata, A.; Fukuyama, T.; Ryu, I.; Wakamatsu, K.; Orita, A.
Chem. Lett. 2020, 49, 409-412.
Revisiting Hydroxyalkylation of Phenols with Cyclic Carbonates
S.-C. Kao, Y.-C. Lin, I. Ryu, Y.-K. Wu.
Adv. Synth. Catal. 2019, 361, 3639-3644.
Kinetically Controlled Fischer Glycosidation under Flow Conditions: A New Method for Preparing Furanosides
Masui, S.; Manabe, Y.; Hirao, K.; Shimoyama, A.; Fukuyama, T.; Ryu, I.; Fukase, K.
Synlett 2019, 30, 397-400.
Electron Transfer-Induced Reduction of Organic Halides with Amines
Fukuyama, T.; Fujita, Y.; Miyoshi, H.; Ryu, I.; Kao, S.-C.; Wu, Y.-K.
Chem. Commun. 2018, 54, 5582-5585.
Formal Total Synthesis of L Ossamine via Decarboxylative Functionalization Using Visible-Light-Mediated Photoredox Catalysis in a Flow System
Inuki, S.; Sato, K.; Fukuyama, T.; Ryu, I.; Fujimoto, Y.
J. Org. Chem. 2017, 82, 1248−1253.
Scalable Flow Synthesis of [6,6]-Phenyl-C61-Butyric Acid Methyl Ester (PCBM) Using a Flow Photoreactor with a Sodium Lamp
Ueda, M.; Imai, N.; Yoshida, S.; Yasuda, H.; Fukuyama, T.; Ryu, I.
Eur. J. Org. Chem. 2017, 2017, 6483-6485.
Flow Dehydration and Hydrogenation of Allylic Alcohols: Application to the Waste-Free Synthesis of Pristane
Furuta, A.; Hirobe, Y.; Fukuyama, T.; Ryu, T.; Manabe, Y.; Fukase, K.
Eur. J. Org. Chem. 2017, 1365–1368.
Efficient Flow Fischer Esterification of Carboxylic Acids with Alcohols Using Sulfonic Acid-Functionalized Silica as Supported Catalyst
Furuta, A.; Fukuyama, T.; Ryu, I.
Bull. Chem. Soc. Jpn. 2017, 90, 607–612.
Efficient Anionic Ring Opening Polymerization of Ethylene Oxide under Microfluidic Conditions
Furuta, A.; Okada, K.; Fukuyama, T.
Bull. Chem. Soc. Jpn. 2017, 90, 838-842.
A Greener Process for Flow C–H Chlorination of Cyclic Alkanes Using in situ Generation and On-Site Consumption of Chlorine Gas
Fukuyama, T.; Tokizane, M.; Matsui, M.; Ryu, I.
React. Chem. Eng. 2016, 1, 613–615.
Flow Update for a Cossy Photocyclization
Fukuyama, T.; Fujita, Y.; Rashid, M. A.; Ryu, I.
Org. Lett. 2016, 18, 5444−5446.
Revisiting the Bromination of C-H Bonds with Molecular Bromine by Using a Photo-Microflow System
Manabe, Y.; Kitawaki, Y.; Nagasaki, M.; Fukase, K.; Matsubara, H.; Hino, Y.; Fukuyama, T.; Ryu, I.
Chem. Eur. J. 2014, 20, 12750-12753.
Innovative Carbonylation Methods
Kawamoto, T.; Fukuyama, T.; Ryu, I.
J. Synth. Org. Chem. Jpn. 2014, 72, 493-505.
Carbonylation in Microflow: Close Encounters of CO and Reactive Species
Fukuyama, T., Totoki, T., Ryu, I.
Green Chem. 2014, 16, 2042-2050
Revisiting the Bromination of C-H Bonds with Molecular Bromine by Using a Photo-Microflow System
Manabe, Y.; Kitawaki, Y.; Nagasaki, M.; Fukase, K.; Matsubara, H.; Hino, Y.; Fukuyama, T.; Ryu, I.
Chem. Eur. J. 2014, 20, 12750-12753
Flow Update for the Carbonylation of 1-Silyl-Substituted Organolithiums under CO Pressure
Fukuyama, T.; Totoki, T.; Ryu, I.
Org. Lett. 2014, 16, 5632-5635.
Flow Carbonylation Using Near-Stoichiometric Carbon Monoxide. Application to Heck Carbonylation
Akinaga, H.; Masaoka, N.; Takagi, K.; Ryu, I.; Fukuyama, T.
Chem. Lett. 2014, 43, 1456-1458.
Flow Giese Reaction Using Cyanoborohydride as a Radical Mediator
Fukuyama, T.; Kawamoto, T.; Kobayashi, M.; Ryu, I.
Beilstein J. Org. Chem. 2013, 9, 1791-1796
Modernized Low Pressure Carbonylation Methods in Batch and Flow Employing Common Acids as a CO Source
Brancour, C., Fukuyama, T.; Mukai, Y.; Skrydstrup, T.; Ryu, I.
Org. Lett. 2013, 15, 2794-2797.
100 Gram Scale Synthesis of a Key Intermediate of Matrix Metalloproteinase Inhibitor in a Continuous-Flow System Based on a Copper-Free Sonogashira Reaction Using an Ionic Liquid as a Catalyst Support
Fukuyama, T.; Rahman, M. T.; Sumino, Y.; Ryu, I.
Synlett 2012, 23, 2279-2283.
J. Synth. Org. Chem. Jpn. 2012, 70, 896-907.
Nitroxide-Mediated Polymerization of Styrene, Butyl Acrylate, or Methyl Methacrylate by Microflow Reactor Technology
Fukuyama, T.; Kajihara, Y.; Ryu, I.; Studer, A.
Synthesis 2012, 44, 2555-255
Koch–Haaf Reaction of Adamantanols in an Acid-tolerant Hastelloy-Made Microreactor
Fukuyama, T.; Mukai, Y.; Ryu, I.
Beilstein J. Org. Chem. 2011, 7, 1288-1293
Continuous Microflow [2 + 2] Photocycloaddition Reactions Using Energy-Saving Compact Light Sources
Fukuyama, T.; Kajihara, Y.; Hino, Y.; Ryu, I.
J. Flow Chem. 2011, 1, 40-45
Microflow Photo-Radical Chlorination of Cycloalkanes
Matsubara, H.; Hino, Y.; Tokizane, M.; Ryu, I.
Chem. Eng. J. 2011, 167, 567-571.
Diastereoselective [2+2] Photocycloaddition of Chiral Cyclic Enone and Cyclopentene Using a Microflow Reactor System
Tsutsumi, K.; Terao, K.; Yamaguchi, H.; Yoshimura, S.; Morimoto, T.; Kakiuchi, K.; Fukuyama, T.; Ryu, I.
Chem. Lett. 2010, 39, 828–829.
Monolithic and Flexible Polyimide Film Microreactors for Organic Microchemical Applications Fabricated by Laser Ablation
Min, K. I.; Lee, T. H.; Park, C. P.; Wu, Z. W.; Girault, H. H.; Ryu, I.; Fukuyama, T., Mukai, Y., Kim, D. P.
Angew. Chem. Int. Ed. 2010, 49, 7063-7067.
Radical Carbonylations Using a Continuous Microflow System
Fukuyama, T.; Rahman, M. T.; Kamata, N.; Ryu, I.
Beilstein J. Org. Chem. 2009, 5, 34.
Addition of Allyl Bromide to Phenylacetylene Catalyzed by Palladium on Alumina and its Application to a Continuous Flow Synthesis
Fukuyama, T.; Kippo, T.; Ryu, I.; Sagae, T.
Res. Chem. Intermed. 2009, 35, 1053-1057.
Microflow Radical Carboaminoxylations with a Novel Alkoxyamine
Wienhöefer, I. C.; Studer, A.; Rahman, M. T.; Fukuyama, T.; Ryu, I.
Org. Lett. 2009, 11, 2457-2460.
Microflow Photo-Radical Reaction Using a Compact Light Source: Application to the Barton Reaction Leading to a Key Intermediate for Myriceric Acid A
Sugimoto, A.; Fukuyama, T.; Sumino, Y.; Takagi, M.; Ryu, I.
Tetrahedron 2009, 65, 1593-1598.
An Automated-Flow Microreactor System for Quick Optimization and Production: Application to 10- and 100-gram Order Productions of a Matrix Metalloproteinase Inhibitor Using a Sonogashira Coupling Reaction
Sugimoto, A.; Fukuyama, T.; Rahman, M. T.; Ryu, I.
Tetrahedron Lett. 2009, 50, 6364-6367.
Spurring Radical Reactions of Organic Halides with Tin Hydride and TTMSS Using Microreactors
Fukuyama, T.; Kobayashi, M.; Rahman, M. T.; Kamata, N.; Ryu, I.
Org. Lett. 2008, 10, 533-536.
Adventures in Inner Space: Microflow Systems for Practical Organic Synthesis
Fukuyama, T.; Rahman, M. T.; Sato, M.; Ryu, I.
Synlett 2008, 2, 151-163.
The Barton Reaction Using a Microreactor and Black Light. Continuous-Flow Synthesis of a Key Steroid Intermediate for an Endothelin Receptor Antagonist
Sugimoto, A.; Sumino, Y.; Takagi, M.; Fukuyama, T.; Ryu, I.
Tetrahedron Lett. 2006, 47, 6197–6200.
Low Pressure Pd-Catalyzed Carbonylation in an Ionic Liquid Using a Multiphase Microflow System
Rahman, M. T.; Fukuyama, T.; Kamata, N.; Ryu, I.
Chem. Commun. 2006, 2236–2238.
Continuous Hydrogenation Reactions in a Tube Reactor Packed with Pd/C
Yoswathananont, N.; Nitta, K.; Nishiuchi, Y.; Sato, M.
Chem. Commun. 2005, 42-45.
Continuous Microflow Synthesis of Butyl Cinnamate by a Mizoroki-Heck Reaction Using a Low Viscosity Ionic Liquids as the Recycling Reaction Medium
Liu, S.; Fukuyama, T.; Sato, M.; Ryu, I.
Org. Process Res. Dev. 2004, 8, 477–481.
Quick execution of [2+2] type photochemical cycloaddition reaction by continuous flow system using a glass-made microreactor
Fukuyama, T.; Hino, Y.; Kamata, N.; Ryu, I.
Chem. Lett. 2004, 33, 1430-1431.
A Copper-free Sonogashira Coupling Reaction in Ionic Liquids and its Application to a Microflow System for Efficient Catalyst Recycling
Fukuyama,T.; Shinmen, M.; Nishitani, S.; Sato, M.; Ryu, I.
Org. Lett. 2002, 4, 1691–1694.
